Fragile Treg cells: Traitors in immune homeostasis?

Fragile Treg cells: Traitors in immune homeostasis?

Blog Article

Regulatory T (Treg) cells play a key role in maintaining immune tolerance and tissue homeostasis.However, in some disease microenvironments, Treg cells exhibit fragility, which manifests as preserved FoxP3 expression accompanied by superhero lollipops inflammation and loss of immunosuppression.Fragile Treg cells are formatively, phenotypically and functionally diverse in various diseases, further complicating the role of Treg cells in the immunotherapeutic response white feather tinsel and offering novel targets for disease treatment by modulating specific Treg subsets.In this review, we summarize findings on fragile Treg cells to provide a framework for characterizing the formation and role of fragile Treg cells in different diseases, and we discuss how this information may guide the development of more specific Treg-targeted immunotherapies.